Expression of mucin‐associated tumor antigens is altered by cell density
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چکیده
منابع مشابه
Uptake of Autologous and Allogenic Tumor Cell Antigens by Dendritic Cells
Background: Dendritic cells (DCs) are professional antigen presenting cells (APCs), and there is considerable interest in their application as a cellular adjuvant for cancer immunotherapy. Previous studies indirectly demonstrated that DCs were able to take up tumor lysate (crude soluble tumor antigens) and also cross-present tumor associated antigens (TAA) which elicits anti-tumor immune respo...
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Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and comp...
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At least three different types of cells are needed for a humoral response to most antigens. The bone marrow-derived lymphocyte (B cell) produces the humoral antibody (1, 2) and is triggered by a cooperating thymus-derived lymphocyte (T cell) to do so (3). A phagocytic cell, the macrophage (M4), is often needed to "process" or "handle" the antigen (4, 5) for this cooperation. The details of thes...
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Adoptive immunotherapy with antibody-based therapy or with T cells transduced to express chimeric antigen receptors (CARs) is useful to the extent that the cell surface membrane protein being targeted is not expressed on normal tissues. The most successful CAR-based (anti-CD19) or antibody-based therapy (anti-CD20) in hematologic malignancies has the side effect of eliminating the normal B cell...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 1997
ISSN: 0020-7136,1097-0215
DOI: 10.1002/(sici)1097-0215(19970729)72:3<457::aid-ijc14>3.3.co;2-g